Dual antiplatelet therapy: optimal timing, management, and duration
نویسندگان
چکیده
منابع مشابه
Dual antiplatelet therapy: optimal timing, management, and duration.
Platelet activation and aggregability play a key role in the genesis of arterial thrombus secondary to plaque rupture. For coronary patients, inhibition of platelet function is crucial to decrease the rate of major adverse cardiac events but may expose them to excess bleeding risk. Switching P2Y12 inhibitors is common, yet the clinical consequences are unknown. The aim of this review is to prov...
متن کاملStent thrombosis and optimal duration of dual antiplatelet therapy after coronary stenting in contemporary practice
The introduction of drug-eluting stents (DES) in the practice of percutaneous coronary intervention (PCI) has substantially reduced angiographic and clinical restenosis but is associated with an increasing propensity for very late stent thrombosis (ST). Among several clinical, lesion, or procedure-related predictors of ST, early discontinuation of dual antiplatelet therapy (DAPT) is the most im...
متن کاملDual antiplatelet therapy -- management in general practice.
BACKGROUND Prasugrel and ticagrelor are two new antiplatelet agents being used in the management of acute coronary syndromes. The number of patients in the community managed on these medications is growing, and thus, it is essential that general practitioners have a good understanding of these agents and their evidence-based applications. OBJECTIVE The pharmacokinetic and pharmacodynamic prop...
متن کاملOptimal duration of dual antiplatelet therapy after drug eluting stent implantation: a network meta-analysis
OBJECTIVE There has been much debate regarding the optimal duration of dual antiplatelet therapy (DAPT) cover after drug eluting stent (DES) implantation. We aimed to assess the relative benefits of shorter and longer durations of DAPT coverage. METHODS We performed a network meta-analysis (NMA) of all the randomized clinical trials (RCT) comparing different time durations of DAPT cover. RE...
متن کاملDuration of dual antiplatelet therapy in acute coronary syndrome
Despite a large volume of evidence supporting the use of dual antiplatelet therapy in patients with acute coronary syndrome, there remains major uncertainty regarding the optimal duration of therapy. Clinical trials have varied markedly in the duration of therapy, both across and within trials. Recent systematic reviews and meta-analyses suggest that shorter durations of dual antiplatelet thera...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Heart Journal - Cardiovascular Pharmacotherapy
سال: 2015
ISSN: 2055-6837,2055-6845
DOI: 10.1093/ehjcvp/pvv015